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From twitch to tetanus for human muscle - experimental data and model predictions for m. triceps surae

机译:从抽搐到破伤风的人体肌肉-m的实验数据和模型预测。肱三头肌

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摘要

In models describing the excitation of muscle by the central nervous system, it is often assumed that excitation during a tetanic contraction can be obtained by the linear summation of responses to individual stimuli, from which the active state of the muscle is calculated. We investigate here the extent to which such a model describes the excitation of human muscle in vivo. For this purpose, experiments were performed on the calf muscles of four healthy subjects. Values of parameters in the model describing the behaviour of the contractile element (CE) and the series elastic element (SEE) of this muscle group were derived on the basis of a set of isokinetic release contractions performed on a special-purpose dynamometer as well as on the basis of morphological data. Parameter values describing the excitation of the calf muscles were optimized such that the model correctly predicted plantar flexion moment histories in an isometric twitch, elicited by stimulation of the tibial nerve. For all subjects, the model using these muscle parameters was able to make reasonable predictions of isometric moment histories at higher stimulation frequencies. These results suggest that the linear summation of responses to individual stimuli can indeed give an adequate description of the process of human muscle excitation in vivo.
机译:在描述中枢神经系统对肌肉的刺激的模型中,通常假定在强直性收缩期间的刺激可以通过对单个刺激的响应进行线性求和来获得,由此可以计算出肌肉的活动状态。我们在这里研究这种模型描述人体肌肉在体内激发的程度。为此,对四个健康受试者的小腿肌肉进行了实验。描述此肌肉群的收缩元件(CE)和系列弹性元件(SEE)行为的模型中的参数值是基于在专用测功机上执行的一组等速释放收缩以及根据形态学数据。对描述小腿肌肉兴奋的参数值进行了优化,以使该模型正确预测等轴测抽搐中的足底屈曲力矩历史,这是由胫神经的刺激引起的。对于所有受试者,使用这些肌肉参数的模型能够对较高刺激频率下的等距矩历史做出合理的预测。这些结果表明,对单个刺激响应的线性求和确实可以充分描述人体内肌肉的刺激过程。

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